Nuvia Ion Exchange Resins are a family of best-in-class ion exchangers designed to provide high binding capacities and/or exceptional resolution depending on chemistry and particle size chosen by the process developer. Their exceptional purification performance and high productivity makes these resins ideal for biosimilar and biotherapeutic downstream processes.
High-throughput experimentation (HTE) was used in this case study in concert with design of experiments (DOE) methodology to study the mass recovery of a basic therapeutic protein (pI 9.2–9.5) using a hydrophobic cation exchange mixed-mode resin.
Bio-Rad now offers two ultra-high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing, and Nuvia Q, which can be used for intermediate and/or final polishing.
Nuvia HR-S Resin is a small-particle-size, high-resolution cation exchange resin designed for intermediate and final polishing purification steps where the separation of closely related biomolecules is challenging.
Nuvia S is an ultra-high capacity, next-generation cation exchange resin built on the industry-proven UNOsphere™ base matrix technology. Nuvia S resin may be used in both the capture and polishing of biotherapeutics.
Nuvia Q is an ultra-high binding capacity anion exchange resin with wide pH and flow rate working ranges ideal for process development. It is the next-generation ion exchange resin of choice for biosimilars, delivering high-concentration feed titers.
Nuvia cPrime is a mixed-mode ion exchange media designed for versatile capture and high recovery across a wide range of salt concentrations and pH in process-scale applications for biosimilar and biotherapeutic purification.
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