Nuvia ion exchange media are a family of best-in-class ion exchangers designed to provide high binding capacities and/or exceptional resolution depending on chemistry and particle size chosen by the process developer. Their exceptional purification performance and high productivity are ideal for biosimilar and biotherapeutic downstream processes.
High-throughput experimentation (HTE) was used in this case study in concert with design of experiments (DOE) methodology to study the mass recovery of a basic therapeutic protein (pI 9.2–9.5) using a hydrophobic cation exchange mixed-mode resin.
Bio-Rad now offers two ultra-high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing, and Nuvia Q, which can be used for intermediate and/or final polishing.
Nuvia HR-S is a small particle size, high-resolution cation exchange media designed for intermediate and final polishing purification steps where the separation of closely related biomolecules is challenging.
Nuvia S is an ultra-high capacity, next-generation cation exchange media built on the industry-proven UNOsphere™ base matrix technology. Nuvia S media may be used in both the capture and polishing of biotherapeutics.
Nuvia Q is an ultra-high binding capacity anion exchange media with wide pH and flow rate working ranges ideal for process development. It is the next-generation ion exchange media of choice for biosimilars, delivering high-concentration feed titers.
Nuvia cPrime is a mixed-mode ion exchange media designed for versatile capture and high recovery across a wide range of salt concentrations and pH in process-scale applications for biosimilar and biotherapeutic purification.
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