Ion Exchange Resins

Achieve High Productivity Using UNOsphere S Cation Exchange Support

Be Productive
In the bioprocess industry, the isolation of biomolecules from crude feedstock is one of the most demanding chromatographic steps in the downstream process.

Biopharmaceutical manufacturers are under increasing economic pressure to reduce drug production costs.

These factors require the media used in the capture step to have very high binding capacities at fast linear velocities while maintaining low column backpressure.

UNOsphere is a patented* new-generation polymeric support, based on a single-step polymerization process that delivers high productivity in the capture step.

* US patent 6,423,666 B1.

Achieve High Productivity Using UNOsphere Q Anion Exchange Support

Be Productive
In the bioprocess industry, the isolation of biomolecules from crude feedstock is one of the most demanding chromatographic steps in the downstream process. Biopharmaceutical manufacturers are under increasing economic pressure to reduce drug production costs. These factors require the media used in the capture step to have very high binding capacities at fast linear velocities, while maintaining low column backpressure.

Based on a single-step polymerization process, UNOsphere is a new-generation polymeric support that delivers high productivity in the capture step.

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Purification of a Monoclonal Antibody Using a Combination of UNOsphere Rapid S and UNOsphere Q Media Ion Exchange Chromatography After Protein A Capture

Introduction
Antibody-based drugs represent a growing segment of the pharmaceutical industry and one of the most promising classes of therapeutic drugs. The demand for protein-based drugs is expected to grow steadily for the foreseeable future. However, production of monoclonal antibody (mAb)–based drugs remains very costly, and solutions to lower production costs are needed. Downstream purification steps are becoming a target for cost reduction. The use of ion exchange chromatography to directly capture MAbs from cell culture streams or as a polishing step after an affinity separation may be a way to reduce costs.

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