Bio-Rad Launches scATAC-Seq Solution for Early Access Customers

Print

Date: 09/19/2018

Enables Genome-Wide Open Chromatin Sequencing at the Single-Cell Level

ddSEQ Single-Cell Isolator
Bio-Rad harnesses its ddSEQ Single-Cell Isolator (pictured) to partition thousands of cell nuclei into individual nanoliter-sized droplets for library preparation.

HERCULES, Calif — September 19, 2018 —— Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb) today announced the early access launch of its scATAC-Seq solution, a single-cell assay for transposase-accessible chromatin using sequencing. The solution harnesses Bio Rad’s ddSEQ Single-Cell Isolator to encapsulate thousands of cell nuclei into nanoliter-sized droplets, in which library preparation for chromatin sequencing occurs. The epigenomics solution enables genome-wide open chromatin sequencing at single-cell resolution.

Researchers studying regulatory biology are increasingly using single-cell gene expression tools such as ATAC-Seq to assess epigenetic differences by analyzing open chromatin regions and nucleosome positioning in regulatory regions and by identifying transcription factors. ATAC-Seq has a two-pronged advantage over other published methods because it does not require separate assays to collect this information, and it does not require millions of cells as starting material. The scATAC-Seq solution has given early access customers the power to study rare cell populations, thereby opening up new applications, such as the ability to study tumor heterogeneity or identify rare cell types in blood.

Bio-Rad’s scATAC-Seq solution enables genome-wide open chromatin sequencing at the single-cell level, leveraging the throughput capabilities of the company’s ddSEQ Single-Cell Isolator to partition thousands of cell nuclei, each into its own nanosized droplet. The solution’s sensitivity is achieved with a hyperactive transposase, which cuts the strands between the nucleosomes into very short fragments for greater resolution.

“The scATAC-Seq solution will specifically allow researchers to ask deeper questions about mechanisms of cell fate, identify the cell types present in heterogeneous tissues, and validate single-cell gene expression data,” said Dan Norton, Senior Product Manager for Bio-Rad’s Digital Biology Group.

In creating the scATAC-Seq solution, Bio-Rad used its expertise in droplets to produce a highly sensitive, high-throughput solution. The ddSEQ Single-Cell Isolator technology enables the processing of thousands of cells at once, in contrast to plate-based systems that can only handle 96 cells per plate. This throughput allows researchers to study immune and cancer cell biology at a deeper, more comprehensive level.

Bio-Rad will present data on how its scATAC-Seq solution enabled the discovery of a large repertoire of epigenomic regulatory elements involved in hematopoiesis and immune responses at the Single Cell Europe Conference in Prague on Friday.

Bio-Rad is sponsoring a Cell Press Webinar on October 10, where an inventor of ATAC-Seq and an early access customer, Jason Buenrostro, PhD, will present his work.

Please visit bio-rad.com/scATAC-Seq to learn more about Bio-Rad’s scATAC-Seq

About Bio-Rad
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb) is a global leader in developing, manufacturing, and marketing a broad range of innovative products for the life science research and clinical diagnostic markets. With a focus on quality and customer service for over 65 years, our products advance the discovery process and improve healthcare. Our customers are university and research institutions, hospitals, public health and commercial laboratories, biotechnology, pharmaceutical, as well as applied laboratories that include food safety and environmental quality. Founded in 1952, Bio-Rad is based in Hercules, California, and has a global network of operations with more than 8,000 employees worldwide. Bio-Rad had revenues exceeding $2.1 billion in 2017. For more information, please visit www.bio-rad.com.

This release may be deemed to contain certain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, without limitation, statements we make regarding our development and launch of new products and our expectations regarding our products. Forward-looking statements generally can be identified by the use of forward-looking terminology such as “will,” “plan”, “believe,” “expect,” “anticipate,” “may,” “can,” “intend,” “estimate,” “continue,” or similar expressions or the negative of those terms or expressions, although not all forward-looking statements contain these words. Such statements involve risks and uncertainties, which could cause actual results to vary materially from those expressed in or indicated by the forward-looking statements. These risks and uncertainties include our ability to develop and market new or improved products, product quality and liability issues, our ability to compete effectively, and international legal and regulatory risks. For further information regarding our risks and uncertainties, please refer to the “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operation” in Bio-Rad’s public reports filed with the Securities and Exchange Commission, including our most recent Annual Report on Form 10-K and our Quarterly Report on Form 10-Q. Bio-Rad cautions you not to place undue reliance on forward-looking statements, which reflect an analysis only and speak only as of the date hereof. We disclaim any obligation to update these forward-looking statements.

Press Contact:
Bio-Rad Laboratories, Inc.
Carolyn Reifsnyder
925-474-9027
carolyn_reifsnyder@bio-rad.com

CG Life
Ken Li
312-532-4675
kli@cglife.com

Sign Up for Bio-Rad Updates!
Enter your email address below to receive your choice of the latest news, promotions, and more.
Get Help

Call us at 00 800 00 BIORAD (00 800 00 24 67 23) or +49 89 3188 4393

Bio-Rad-Launches-scA_1537378901 [x-forwarded-proto] = [http] [x-forwarded-port] = [80] [x-forwarded-for] = [34.224.102.60, 10.232.2.216] [accept] = [text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8] [if-modified-since] = [Fri, 16 Nov 2018 08:27:59 GMT] [seourl] = [/en-de/life-science-research/news/bio-rad-launches-scatac-seq-solution-for-early-access-customers] [x-amzn-trace-id] = [Root=1-5c46fa80-96edd078c57615c07f3f9070] [x-forwarded-server] = [lsds-prod-s.br.aws-livesite.io] [x-forwarded-host] = [www.bio-rad.com] [x-query-string] = [ID=Bio-Rad-Launches-scA_1537378901] [host] = [10.232.0.21:1776] [x-request-uri] = [/en-de/life-science-research/news/bio-rad-launches-scatac-seq-solution-for-early-access-customers] [connection] = [Keep-Alive] [accept-encoding] = [gzip] [user-agent] = [CCBot/2.0 (https://commoncrawl.org/faq/)] Vertical/VerticalArticleDetail pageStyleKey life-science-research/news/bio-rad-launches-scatac-seq-solution-for-early-access-customers LSR 11/26/13 02:09 PM en_US true internet/generic 2018-07-20 22:56:17 /default/main/bio-rad/STAGING 1385503790256 UK,AT,BE,BG,HR,CZ,CY,DK,EE,FI,FR,DE,GR,HU,IE,IT,LV,LT,LU,MT,NL,PL,PT,RO,SK,SI,ES,SE templatedata/internet/generic/data/GNL/page_generic_footer_b2c_1385503901_UK.xml page_generic_footer_b2c /default/main/bio-rad/WORKAREA/default jcc1tp9j 2017-10-27 13:13:51 true jcc1tp9j templatedata/internet/generic/data/GNL/page_generic_footer_b2c_1385503901_UK.xml GNL N /default/main/bio-rad en 11/27/23 02:11 PM 1530035376581 2018-07-20 22:56:17 /default/main/bio-rad/WORKAREA/default/templatedata/internet/generic/data/GNL/page_generic_footer_b2c_1385503901_UK.xml footer-page 1 1385503790256 page_generic_footer_b2c <div class="links"> <h4>Support</h4> <ul> <li><a class="msdsLink wtclass" href="/en-uk/literature-library">MSDS</a></li> <li><a class="cofaLink wtclass" href="/en-uk/life-science-research/support/certificate-of-analysis">Certificate of Analysis</a></li> <li><a class="qcinsertsLink wtclass" href="http://myeinserts.qcnet.com/" target="_blank" rel="noopener noreferrer">QC Inserts</a></li> <li><a class="expertCSLink wtclass" href="/en-uk/life-science-research/purchase-service-programs/expert-care-service">Expert Care Service</a></li> <li><a class="feedBackLink wtclass" href="javascript:openAjaxOverlay('/bio-rad/Standalone/FeedbackOverlay.page?standalonePage=true','Feedback')">Feedback</a></li> <li><a class="contactUSLink wtclass" href="/en-uk/contact-us">Contact Us</a></li> </ul> </div> <div class="links"> <h4>Ordering</h4> <ul> <li><a id="quickOrderLink" class="quickOrderLink wtclass" name="quickOrderLink" href="javascript:openAjaxOverlay('/evportal/portlets/ordering/quickOrderOverlayContent.jsp?quickorder_location=Footer')">Quick Order</a></li> <li><a class="mybioradLink wtclass" href="/en-uk/my-bio-rad">My Bio-Rad</a></li> <li><a id="footer_orderLink" class="orderhistoryLink wtclass" href="javascript:void(0);">Order History</a></li> <li><a id="footer_quoteLink" href="javascript:void(0);">Quote History</a></li> <li><a class="supplycentersLink wtclass linkgeneration" href="/_locale/_defaultVerticalUrl/purchase-service-programs/supply-centre-programme">Supply Centres</a></li> <li><a class="returnpolicyLink wtclass linkgeneration" href="javascript:openAjaxOverlay('/webroot/web/html/returnPolicy-en-EM.html','Return and Refund Policy');">Return and Refund Policy</a></li> </ul> </div> <div class="links"> <h4>Our Products</h4> <ul> <li><a class="lsrLink wtclass" href="/en-uk/life-science-research">Life Science Research</a></li> <li><a class="cdLink wtclass" href="/en-uk/clinical-diagnostics">Clinical Diagnostics</a></li> <li><a class="infLink wtclass" href="/en-uk/spectroscopy">Spectroscopy</a></li> <li><a class="psLink wtclass" href="/en-uk/process-separations">Process Separations</a></li> <li><a class="fsLink wtclass" href="/en-uk/food-science">Food Science</a></li> <li><a class="lseLink wtclass" href="/en-uk/education">Life Science Education</a></li> <li><a class="selectionguideLink wtclass" href="/featured/en/selection-guides.html">Selection Guides</a></li> <li><a class="featuredproductsLink wtclass" href="/featured/en/featured-products.html">Featured Products</a></li> </ul> </div> <div class="links links2"> <h4>Corporate</h4> <ul> <li><a class="aboutbioradLink wtclass" href="/en-uk/corporate/about-bio-rad">About Bio-Rad</a></li> <li><a class="careersLink wtclass" href="/en-uk/corporate/careers">Careers</a></li> <li><a class="irLink wtclass" href="/en-uk/corporate/investor-relations">Investor Relations</a></li> <li><a class="coLink wtclass" href="/en-uk/corporate/community-outreach">Community Outreach</a></li> <li><a class="pteLink wtclass" href="/en-uk/corporate/protecting-environment">Protecting the Environment</a></li> <li><a class="newsroomLink wtclass" href="/en-uk/corporate/newsroom">Newsroom</a></li> </ul> </div> /webroot/web/html footer_page_b2c_en_UK.html /webroot/web/html/footer_page_b2c_en_UK.html Karen Moss Footer page Footer 11/26/13 02:09 PM 11/27/23 02:11 PM UK,AT,BE,BG,HR,CZ,CY,DK,EE,FI,FR,DE,GR,HU,IE,IT,LV,LT,LU,MT,NL,PL,PT,RO,SK,SI,ES,SE en GNL /GNL N 0 en-de Home Trademarks Site Terms Terms & Conditions Imprint EU Recycle Program Privacy Change Cookie Setting <script type="text/javascript">$(document).ready(function () {$(".links2").append('<style>.social-links-br {float: left;margin-right: 10px;}.social-links-br img {width: 20px;height: 20px;margin-right: 5px}</style><div class="social-links-br"><a class="no-target-style" href="https://www.linkedin.com/company/bio-rad?trk=top_nav_home" target="_blank"><img src="/webroot/web/images/general/icons/linkedin_round_40x40.png" alt="Bio-Rad LinkedIn"></a><a class="no-target-style" href="https://www.youtube.com/user/BioRadLifeScience" target="_blank"><img src="/webroot/web/images/general/icons/youtube-icon-rnd-40x40.png" alt="Bio-Rad YouTube"></a><a class="no-target-style" href="https://twitter.com/BioRadLifeSci" target="_blank"><img src="/webroot/web/images/general/icons/twitter_round_40x40.png" alt="Bio-Rad Twitter"></a><a class="no-target-style" href="https://www.facebook.com/biorad/" target="_blank"><img src="/webroot/web/images/general/icons/facebook-icon-rnd-40x40.png" alt="Bio-Rad Facebook"></a><a class="no-target-style" href="https://www.instagram.com/bioradlabs/" target="_blank"><img src="/webroot/web/images/general/icons/instagram-icon-rnd-40x40.png" alt="Bio-Rad Instagram"></a></div>');});</script>Copyright &copy; {0} Bio-Rad Laboratories, Inc. All rights reserved. This page was last edited on {0} true true true true True GTM-MJ2DN2S de DE en LSR life-science-research life-science-research /prd/en/DE/direct/biorad?ts=1&cmd=OrdersWorkspaceDisplay /prd/en/DE/direct/biorad?ts=1&cmd=QuotesWorkspaceDisplay /prd/en/DE/direct/biorad?ts=1&cmd=InvoiceWorkspaceDisplay&_Tab=Invoice false false true false true true 1040988879 LHsYCOu_wQMQz_Ww8AM window.google_tag_params true 272-THL-329 username CartID_ WT_FPC <script type="text/javascript">$.ajax({url: document.location.protocol + '//munchkin.marketo.net/munchkin.js',dataType: 'script',cache: true,success: function() {Munchkin.init('044-CBN-599');}});</script> <script type="text/javascript" src="/evportal/framework/skins/evolution/js/proxyMunchkin.js"></script> 2019
To give you the very best experience, the cookie settings on Bio-Rad.com are set to "allow all cookies". To change your settings please click  here.  Close