UNOsphere™ Cation Exchange Resin

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UNOsphere Cation Exchange Resin

Overview

Specifications
  UNOsphere™ Q UNOsphere S
Type of ion exchanger Strong anion Strong cation
Functional group -N+(CH3)3 -SO3-
Total ionic capacity 120 µeq/ml 280 µeq/ml
Dynamic binding capacity*    
   150 cm/hr 180 mg BSA/ml 60 mg IgG/ml
   600 cm/hr 125 mg BSA/ml 30 mg IgG/ml
Shipping counterion Cl- Na+
Median particle size 120 µm 80 µm
Recommended linear flow rate range** 50–1,200 cm/hr 50–1,200 cm/hr
Chemical stability    
   1.0 M NaOH (20°C) Up to 10,000 hr Up to 10,000 hr
   1.0 M HCl (20°C) Up to 200 hr Up to 200 hr
Volume changes**    
   pH 4–10 <5% <5%
   0.01–1.0 M NaCl <5% <5%
pH stability 1–14 1–14
Autoclavability Yes Yes
Antimicrobial agent 20% ethanol 20% ethanol
Regeneration 1–2 M NaCl 1–2 M NaCl
Storage conditions 20% ethanol or 0.1 M NaOH 20% ethanol or 0.1 M NaOH

* 10% breakthrough capacity determined with 4.5 mg/ml human IgG (UNOsphere S) and 2.0 mg/ml BSA (UNOsphere Q) in a 1.1 x 20 cm column.
** UNOshpere packed into a 20 cm bed height and run at 1,200 cm/hr generates less than 2 bar backpressure.

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UNOsphere ion exchange resins are designed to meet the increasing needs of the biopharmaceutical industry for high-productivity chromatographic resin. UNOsphere, a hydrophilic polymeric support, delivers high productivity through high binding capacity and low backpressures. The single-step polymerization process produces a support unsurpassed in quality and batch-to-batch reproducibility.

UNOsphere S support is used for strong cation exchange chromatography. UNOsphere Rapid S resin builds on the properties and features of the UNOsphere family of supports with enhanced chemistries that overcome the pH shift that occurs with conductivity transitions.

Key Features

  • Efficient capture of biopharmaceutical molecules from crude feedstreams
  • Large pores that result in ultrahigh binding capacities at fast linear velocities
  • Hydrophilic polymeric beads engineered for high mechanical stability and low backpressures
  • Robust polymer designed to withstand repetitive clean-in-place cycles
  • Optimized to operate under 2 bar backpressure at velocities of 1,200 cm/hr
  • Stable to 1 M NaoH exposure to 10,000 hr
  • Availability in biopharmaceutical quantities
  • Fully supported for regulatory submissions

 

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UNOsphere S Support

1560111
25 ml, strong cation exchange chromatography media, 80 μm particle size

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UNOsphere S Support

1560113
100 ml, strong cation exchange chromatography media, 80 μm particle size

1 1560113 /templatedata/internet/product_SKU/data/LSR/Chromatography/Chromatography-Media/156-0113_0921120701188.xml 1560113 09/21/09 12:07 PM N en 09/21/19 12:07 PM true true internet/product_SKU AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA LSR 2017-11-14 07:08:02 1560113-unosphere-s-support 1560113 UNOsphere S Support UNOsphere S Support 100 ml, strong cation exchange chromatography media, 80 μm particle size 100 ml, strong cation exchange chromatography media, 120 μm particle size 100 ml, strong cation exchange chromatography media, 80 μm particle size /webroot/web/images/ps/products/ion_exchange_media/sku_thumb/global/156-0113_tn.jpg /webroot/web/images/ps/products/ion_exchange_media/sku_view/global/156-0113_view.jpg /webroot/web/images/ps/products/ion_exchange_media/sku_feature/global/156-0113_feature.jpg UNOsphere S Support #156-0115 preview RepEx UNOsphere S Support #156-0115 100 ml, strong cation exchange chromatography media, 80 μm particle size 1560113, unosphere, s, support, strong, cation, exchange, iex, ion, chromatography, media, medium, resin, protein, separation, purification, 80um, 80, particle, size 09/21/09 12:07 PM 09/21/19 12:07 PM AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA en LSR /LSR/Chromatography/Chromatography-Media N 0 false false false /prd/en/CA/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=1560113&CartQuote=QT&quantity= false true false $415.00 false null /prd/en/CA/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=1560113&AddToDefaultWishList=true&quantity= true false true true false true true true /prd/en/CA/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=1560113&quantity= 1560113
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UNOsphere S Support

156-0115
500 ml, strong cation exchange chromatography media, 80 μm particle size

2 1560115 /templatedata/internet/product_SKU/data/LSR/Chromatography/Chromatography-Media/156-0115_0921120701209.xml 1560115 09/21/09 12:07 PM N en 09/21/19 12:07 PM true true internet/product_SKU AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA LSR 2017-11-14 07:08:02 1560115-unosphere-s-support 1560115 UNOsphere S Support UNOsphere S Support 500 ml, strong cation exchange chromatography media, 80 μm particle size 500 ml, strong cation exchange chromatography media, 120 μm particle size 500 ml, strong cation exchange chromatography media, 80 μm particle size /webroot/web/images/ps/products/ion_exchange_media/sku_thumb/global/156-0115_tn.jpg /webroot/web/images/ps/products/ion_exchange_media/sku_view/global/156-0115_view.jpg /webroot/web/images/ps/products/ion_exchange_media/sku_feature/global/156-0115_feature.jpg UNOsphere S Support #156-0117 RepEx UNOsphere S Support #156-0117 500 ml, strong cation exchange chromatography media, 80 μm particle size 1560115, unosphere, s, support, strong, cation, exchange, iex, ion, chromatography, media, medium, resin, protein, separation, purification, 80um, 80, particle, size 09/21/09 12:07 PM 09/21/19 12:07 PM AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA en LSR /LSR/Chromatography/Chromatography-Media N 0 false false false /prd/en/CA/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=1560115&CartQuote=QT&quantity= false true false null false null /prd/en/CA/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=1560115&AddToDefaultWishList=true&quantity= true false true true false true true true /prd/en/CA/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=1560115&quantity= 156-0115
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UNOsphere S Support

156-0117
10 L, strong cation exchange chromatography media, 80 μm particle size

3 1560117 /templatedata/internet/product_SKU/data/LSR/Chromatography/Chromatography-Media/156-0117_0921120701146.xml 1560117 09/21/09 12:07 PM N en 09/21/19 12:07 PM true true internet/product_SKU AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA LSR 2017-11-14 07:08:02 1560117-unosphere-s-support 1560117 UNOsphere S Support UNOsphere S Support 10 L, strong cation exchange chromatography media, 80 μm particle size 10 L, strong cation exchange chromatography media, 80 μm particle size 10 L, strong cation exchange chromatography media, 80 μm particle size /webroot/web/images/ps/products/ion_exchange_media/sku_thumb/global/156-0117_tn.jpg /webroot/web/images/ps/products/ion_exchange_media/sku_view/global/156-0117_view.jpg /webroot/web/images/ps/products/ion_exchange_media/sku_feature/global/156-0117_feature.jpg RepEx 156-0117 10 L, strong cation exchange chromatography media, 80 μm particle size 09/21/09 12:07 PM 09/21/19 12:07 PM AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA en LSR /LSR/Chromatography/Chromatography-Media N 0 1560117, unosphere, s, support, strong, cation, exchange, iex, ion, chromatography, media, medium, resin, protein, separation, purification, 80um, 80, particle, size, analytical, semi-preparative, process, scale false false false /prd/en/CA/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=1560117&CartQuote=QT&quantity= false true false null false null /prd/en/CA/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=1560117&AddToDefaultWishList=true&quantity= false false true true false true false true /prd/en/CA/adirect/biorad?cmd=ajaxAddToCart&AddToCartProductID=1560117&quantity= 156-0117
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(Discontinued)UNOsphere™ Rapid S Media

1560211
UNOSphere Rapid S Media is no longer available. Please use UNOsphere S or Nuvia™ HR-S Media as alternative products.

This product is no longer available. Please contact technical support for more information on replacement product.
(Discontinued)UNOsphere™ Rapid S Media

1560213
UNOSphere Rapid S Media is no longer available. Please use UNOsphere S or Nuvia™ HR-S Media as alternative products.

This product is no longer available. Please contact technical support for more information on replacement product.
Number Description Options
4110109 Instruction Manual, UNOsphere Q and S Ion Exchange Media, Rev C Click to download
10010339 Instruction Manual, UNOsphere Rapid S Media, Rev A Click to download
2678 UNOsphere™ S Resin Technical Data, Ver D Click to download [ Add to Cart (Free) ]
2669 UNOsphere™ S Cation Exchange Resin Product Information Sheet, Ver D Click to download
5734 UNOsphere Rapid S Media Product Information Sheet, Rev B Click to download [ Add to Cart (Free) ]
6983 Native and Recombinant Protein Purification Resins/Media Selection Card Click to download
6789 IgG Polyclonal Antibody Purification Resin Selection Card, Ver A Click to download
6867 UNOsphere™ Chromatography Resins Publications List, Ver A Click to download
2774 Purification of Transgenic Antibody From Corn Seed Using UNOsphere S and CHT Ceramic Hydroxyapatite Supports, Rev A Click to download
2780 Purification of Murine IgG1 Using UNOsphere S and CHT Ceramic Hydroxyapatite Chromatography, Rev A Click to download [ Add to Cart (Free) ]

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