Human MMP and TIMP Assays

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Bio-Plex Pro Human MMPs and TIMPs Multiplex Assays

Overview

Available Bio-Plex Pro™ Human MMP and TIMP Assays
Matrix Metalloproteinase
(MMP) Analytes
9-Plex Panel
(171-AM001M)
Singleplex Sets
Bead Regions*
MMP-1 171-BM001M 43
MMP-2 171-BM002M 26
MMP-3 171-BM003M 45
MMP-7 171-BM004M 66
MMP-8 171-BM005M 37
MMP-9 171-BM006M 55
MMP-10 171-BM007M 62
MMP-12 171-BM008M 53
MMP-13 171-BM009M 47

Tissue Inhibitor of Matrix Metalloproteinase (TIMPs)
4-Plex Panel
(171-AM002M)
Bead Regions
TIMP-1 21
TIMP-2 64
TIMP-3 52
TIMP-4 35

* You can design an Express “You Mix” multiplex kit with any combination of the MMP analytes. Express assays are configured on www.bio-rad.com/assaybuilder and are delivered to you. You mix the coupled magnetic beads and detection antibodies prior to use.

MMP and TIMP Classifications
Collagenases Gelatinases Stromelysins
MMP-1
MMP-8
MMP-13
MMP-2
MMP-9
MMP-3
MMP-10
Metalloelastase Inhibitors Matrilysins
MMP-12 TIMP-1
TIMP-2
TIMP-3
TIMP-4
MMP-7
 
Bio-Plex® Multiplex Immunoassays Analyte Guide Summer 2014

Use the Bio-Plex analyte guide to explore our analyte offerings, find new assays, and review performance characteristics.

Download Interactive PDF

Bio-Plex® Technology and Applications

The Bio-Plex Pro™ assays for human matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) consist of panels of 9 MMPs and 4 TIMPs.

Analytes in the MMP Panel

  • MMP-1
  • MMP-2
  • MMP-3
  • MMP-7
  • MMP-8
  • MMP-9
  • MMP-10
  • MMP-12
  • MMP-13

Analytes in the TIMP Panel

  • TIMP-1
  • TIMP-2
  • TIMP-3
  • TIMP-4

MMPs have many different functions and actions in the body, whereas TIMPs work to inhibit the actions of MMPs. Studying MMPs and their inhibitors, TIMPs, together can reveal disruptions in the balance of these two proteins, providing insights into disease states.

These immunoassays are built on magnetic beads to enable robust quantification of multiple proteins in human samples for research involving the conditions and disease pathways listed below:

Associated Research

  • Cancer
  • Autoimmune disease
  • Cardiovascular disease
  • Infectious disease
  • Neurology

Associated Pathways

  • Inflammation
  • Wound healing
  • Metastasis
  • Apoptosis
  • Angiogenesis
  • Tumor invasion

Key Features

  • Magnetic beads for simplified plate processing
  • Custom configurable ordering options
  • Single-level quality controls with lot-specific ranges
  • Assay quick guide to get you started right away
  • High-quality design for robust and reproducible measurements

Other Assay Formats Available

Instrument Compatibility

Compatible with these readers and wash stations:

More Information

To learn more about performance characteristics or how to set up your MMP and TIMP assays for optimal performance and sensitivity, refer to the documents listed below:

See how Bio-Plex instruments and assays benefit researchers studying heart disease, leukemia, melanoma, and other cancers.

 

Related Products

Coming Soon: Bio-Plex Pro™ Human Inflammation Assays
For the first time, the most popular biomarkers of inflammation from the TNF superfamily proteins, IFN family proteins, Treg cytokines, and MMPs can be measured using a single multiplex kit. Bio-Plex Pro Human Inflammation Assays will be available in larger 24-plex and 37-plex screening panels and a pathway-focused Treg 12-plex panel, along with singleplex and custom-configured assays.

Sign up now to learn more about this product and receive special offers.

Bio-Plex Pro™ Human MMP Panel, 9-Plex

171-AM001M
1 x 96-well, includes coupled magnetic beads, detection antibodies, standards, control, buffers, diluents, streptavidin-PE, 96-well plate, and sealing tape for the detection of 9 matrix metalloproteinases

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Bio-Plex Pro™ Human TIMP Panel, 4-Plex

171-AM002M
1 x 96-well, includes coupled magnetic beads, detection antibodies, standards, control, buffers, diluents, streptavidin-PE, 96-well plate, and sealing tape for the detection of 4 tissue inhibitors of matrix metalloproteinases

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Bio-Plex Pro Human MMP-1 Singleplex Set
Bio-Plex Pro™ Human MMP-1 Singleplex Set

171-BM001M
1 x 96-well, includes magnetic capture beads and detection antibodies, for the detection of MMP-1

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Bio-Plex Pro Human MMP-2 Singleplex Set
Bio-Plex Pro™ Human MMP-2 Singleplex Set

171-BM002M
1 x 96-well, includes magnetic capture beads and detection antibodies, for the detection of MMP-2

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Bio-Plex Pro Human MMP-3 Singleplex Set
Bio-Plex Pro™ Human MMP-3 Singleplex Set

171-BM003M
1 x 96-well, includes magnetic capture beads and detection antibodies, for the detection of MMP-3

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Bio-Plex Pro Human MMP-7 Singleplex Set
Bio-Plex Pro™ Human MMP-7 Singleplex Set

171-BM004M
1 x 96-well, includes magnetic capture beads and detection antibodies, for the detection of MMP-7

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Bio-Plex Pro Human MMP-8 Singleplex Set
Bio-Plex Pro™ Human MMP-8 Singleplex Set

171-BM005M
1 x 96-well, includes magnetic capture beads and detection antibodies, for the detection of MMP-8

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Bio-Plex Pro Human MMP-9 Singleplex Set
Bio-Plex Pro™ Human MMP-9 Singleplex Set

171-BM006M
1 x 96-well, includes magnetic capture beads and detection antibodies, for the detection of MMP-9

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Bio-Plex Pro Human MMP-10 Singleplex Set
Bio-Plex Pro™ Human MMP-10 Singleplex Set

171-BM007M
1 x 96-well, includes magnetic capture beads and detection antibodies, for the detection of MMP-10

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Bio-Plex Pro Human MMP-12 Singleplex Set
Bio-Plex Pro™ Human MMP-12 Singleplex Set

171-BM008M
1 x 96-well, includes magnetic capture beads and detection antibodies, for the detection of MMP-12

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Bio-Plex Pro Human MMP-13 Singleplex Set
Bio-Plex Pro™ Human MMP-13 Singleplex Set

171-BM009M
1 x 96-well, includes magnetic capture beads and detection antibodies, for the detection of MMP-13

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Number Description Options
6335 Bio-Plex® Multiplex Immunoassays Analyte Guide, Interactive PDF, Rev D Click to download
6551 Bio-Plex Pro Human MMP and TIMP Assays Product Information Sheet, Rev B Click to download
10041639 Instruction Manual, Bio-Plex Pro Human MMP Assays, Rev A Click to download
10041640 Instruction Manual, Bio-Plex Pro Human TIMP Assays, Rev A Click to download
10041637 Instruction Manual, Bio-Plex Pro Human MMP Assays Quick Guide, Rev A Click to download
10041638 Instruction Manual, Bio-Plex Pro Human TIMP Assays Quick Guide, Rev A Click to download