Foresight™ Prepacked Chromatography Filter Plates

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Overview

Using High-Throughput (HT) Methods to Accelerate DOE

High-throughput experimentation (HTE) was used in this case study in concert with design of experiments (DOE) methodology to study the mass recovery of a basic therapeutic protein (pI 9.2–9.5) using a hydrophobic cation exchange mixed-mode resin.

Foresight™ Prepacked Chromatography Plates and Columns Selection Guide
Foresight Plates

Foresight plates are 96-well filter plates prepacked with 20 µl of chromatography media in each well.

Foresight RoboColumn Units

Foresight RoboColumn units are offered as single rows of eight prepacked microcolumns. Foresight RoboColumn units are ideal for high-throughput (HT) process development.

Foresight Columns

Foresight columns are ideal for confirming the operational window obtained through design of experiments (DOE) in trials with Foresight plates and/or Foresight RoboColumn units.

Applications

Foresight plates can be used for HT evaluation of various binding, elution, or wash conditions for different chromatography media. They can be processed using manual or automated robotic systems, and sample collection may be achieved through centrifugation or vacuum manifold techniques.

Foresight RoboColumn units are fully compatible with robotic liquid handling systems, allowing process developers to perform automated HT parallel media screening and/or small-scale method development. Multiple rows up to 12 can be combined to form a 96-column array, allowing users to evaluate various chromatography media and conditions in parallel.

Foresight columns may be used for media screening experiments and/or small-scale method development. Foresight columns have standard HPLC connections, which make them compatible with the NGC™ chromatography system and other liquid chromatography systems.

Physical Dimensions

Standard 96-well plate format
128 × 86 × 33 mm

1 × 8 row
128 × 86 × 14 mm

8 × 20 mm (1-ml column)
8 × 100 mm (5-ml column)

Working Volume

<900 µl

200–600 µl

1–5 ml

Recommended Flow Rate, cm/hr

N/A

16–1,000

59.5-119 (1-ml column)
287.5-595 (5-ml column)

Maximum Pressure, bar (psi)

N/A

8 (116)

30 (435)

Media Types Available

UNOsphere™ Q, UNOsphere S, UNOsphere Rapid S; Nuvia™ Q, Nuvia S, Nuvia™ cPrime™; CHT™ Type I, CHT Type II

Ordering Information
Foresight™ Filter Plates and Columns Workflow

Foresight chromatography filter plates and columns are prepacked with a range of Bio-Rad’s process chromatography media, offering process scientists convenience and reliability for their high-throughput (HT) experimentation needs. Their robust design allows process scientists to use the prepacked formats through the entire purification development cycle, from HT media screening to small-scale methods development and scale-up optimization.
Learn more


Purification scale-up workflow shows the use of HT screening and design of experiments (DOE) to define an operational window for biomanufacturing.

 

Foresight Prepacked Chromatography Filter Plates are prepacked with a range of Bio-Rad’s process chromatography resins, offering process scientists convenience and reliability for their high-throughput (HT) experimentation needs.

Features and Benefits of Foresight Prepacked Chromatography Filter Plates

  • Prepacked, ready-to-use formats designed to save process development time
  • Different experimental conditions to better define an operational window can be evaluated
  • HT experiments with minimal sample requirements can be performed
  • Available in a variety of chromatography media modes designed for large-scale bioprocess
  • Compatible with robotic liquid handling workstations

The Foresite™Instruction Manual describes how to use Foresight Filter Plates prepacked with Bio-Rad chromatography resins.

Other formats available:

Learn more about Foresight™ Prepacked Column and Plate formats and applications.


Chromatography Resins Available in Foresight Prepacked Columns and Plates
Chromatography Resin
Mode
UNOsphere™ Q Strong anion
UNOsphere S Strong cation
UNOsphere Rapid S Strong cation
Nuvia™ Q Strong anion
Nuvia S Strong cation
Nuvia™ cPrime™ Mixed mode
Hydrophobic: cationic
CHT™ Type I — 40 μm particle size Mixed mode
Metal affinity: cationic
CHT Type II — 40 µm particle size Mixed mode
Metal affinity: cationic
  

 

Filter membrane 1.2 µm Supor (polyethersulfone), glass fiber (borosilicate glass without binder), and polypropylene/polyethylene (PP/PE) nonwoven media
Recommended maximum working volume 880 µl/well

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Foresight™ MPC™ Type I Plates, 40 µm, 20 µl
Foresight™ MPC™ Type I Plates, 40 µm, 20 µl

7324785
2 x 96-well plates, 20 µl, filter plate prepacked with MPC Type I mixed-mode chromatography resin, 40 µm particle size

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Foresight™ Nuvia™ HR-S Plates, 20 µl
Foresight™ Nuvia™ HR-S Plates, 20 µl

7324707
2 x 96-well plates, 20 µl, filter plate prepacked with Nuvia HR-S strong cation exchange chromatography resin

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Foresight™ UNOsphere SUPrA™ Plates, 20 µl
(Discontinued) Foresight™ UNOsphere SUPrA™ Plates, 20 µl

7324709
2 x 96-well plates, 20 µl, filter plate prepacked with UNOsphere SUPrA affinity chromatography resin

This product is no longer available. Please contact technical support for more information on replacement product.
Foresight™ UNOsphere™ Q Plates

7324714
2 x 96-well plates, 20 μl, filter plate prepacked with UNOsphere Q strong anion exchange chromatography media

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Foresight™ UNOsphere™ S Plates

7324710
2 x 96-well plates, 20 μl, filter plate prepacked with UNOsphere S strong cation exchange chromatography media

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Foresight™ UNOsphere™ Rapid S Plates

7324712
Foresight UNOsphere Rapid S Plates are no longer available. Please use Foresight UNOsphere S or Foresight™ Nuvia™ HR-S Plates as alternative products.

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Foresight™ Nuvia™ Q Plates

7324703
2 x 96-well plates, 20 μl, filter plate prepacked with Nuvia Q strong anion exchange chromatography media

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Foresight™ Nuvia™ S Plates

7324701
2 x 96-well plates, 20 μl, filter plate prepacked with Nuvia S strong cation exchange chromatography media

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Foresight™ Nuvia™ cPrime™ Plates

7324705
2 x 96-well plates, 20 μl, filter plate prepacked with Nuvia cPrime hydrophobic cation exchange chromatography media

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Foresight™ CHT™ Type I Plates

7324716
2 x 96-well plates, 20 μl, filter plate prepacked with CHT ceramic hydroxyapatite Type I multimodal chromatography media, 40 μm particle size

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Foresight™ CHT™ Type II Plates

7324718
2 x 96-well plates, 20 μl, filter plate prepacked with CHT ceramic hydroxyapatite Type II multimodal chromatography media, 40 μm particle size

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Number Description Options
6498 Lab-Scale Protein Purification – Column and Cartridge Selection Guide, Rev C Click to download [ Add to Cart (Free) ]
6297 Foresight™ Prepacked Plates and Columns Product Information Sheet, Rev B Click to download [ Add to Cart (Free) ]
10024413 Instruction Manual, Foresight™ Chromatography Media Filter Plates, Rev A Click to download
10024831 Instruction Manual, Foresight™ Chromatography Media Columns 1 and 5 ml, Rev A Click to download
10027565 Instruction Manual, Foresight™ RoboColumn Units 200 and 600 µl, Rev A Click to download