Bio-Rad Process Skids

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Overview

Bio-Rad Process Chromatography Skid 00 Video


The versatile Bio-Rad process chromatography skid 00 can be customized for different applications using a core platform and integrating optional hardware. Each system is optimized to the column diameter and process requirements. To learn more click on the video.

Bio-Rad Process Chromatography Skid 00 Specifications
Flow rate 5–120 L/hr
Operating pressure Up to 6 bar at column inlet
Flowmeter accuracy Maximum error: 0.35% of the measured value
Dilution accuracy Maximum error: 3% of the measured value
Tubing dimensions ID 4.8 mm after the pump
ID 6.35 mm before the pump
Temperature range 2–30°C (60°C for CIP)
Pump Membrane pump technology
Flowmeter Magnetic
UV wavelength range 190–740 nm (one wavelength at a time)
Conductivity range 0–500 mS/cm
pH range 0–14
Bubble trap 0.2 L acrylic/glass tube equipped with :
  • 2 level sensors (ultrasonic technology)
  • 1 drain valve
  • 1 sterile air injection valve (0.4 bar)
Valves Pneumatic membrane valves
Mixer Stainless steel static mixer
Air sensor Optical fiber technology, noninvasive
Pressure sensor Equipped with stainless steel membrane
Material and certificates for wetted parts Cells and valves body: PEEK
Flowmeters: PFA
Valve membrane: EPDM
Tubing: FEP
Stainless steel: 316 L, 1.4404 for wetted parts
Bubble trap: Acrylic or glass
All wetted parts in compliance with FDA requirements
3.1b certificates delivered with stainless steel parts
Surface finish Ra: <0.4 µm
Back pressure (without column, with water) At 50 L/H: 0.4 bar
At 80 L/H: 1.2 bar
At 120 L/H: 1.8 bar
Degree protection IP55
Weight 135 kg
Fitting Sanitary fittings with plastic nuts
Dimensions (W x D x H) 750 x 610 x 1,060 mm (without control PC)
Power supply 220 V 1p 50/60 Hz (or 115 V 1p 50/60 Hz)
Air supply 6 bar
Control PLC: OMRON
SCADA: iFix 5.0
PC: Laptop Dell E6400
Intel Core 2 2.4 GHz
HD: 80 GB
Screen: 14.1
Support 4 feet, installation on a lab desk
Sanitization of Bio-Rad Process Chromatography Skid 00

 

Process chromatography equipment must provide a very high level of cleanability to meet the requirements of various regulatory agencies. The efficiency of the cleaning process must satisfy regulations, norms, and standards.

In Bio-Rad bulletin 6108, it is demonstrated that Bio-Rad process chromatography skid 00 can be completely sanitized after bacterial contamination. The wetted surfaces of the fluid path were contaminated with strains of Bacillus subtilis and Serratia marcescens, then tested for sterility after sanitization with 1 N NaOH.

 

Learn more

Specifications
Pressure rating   Up to 6 bar
Temperature range   Ambient: 4–30°C
Process fluids: 4–60°C
Inline dilution capabilities   1:2 to 1:10
Gradient capabilities   10–90%
Material Process tube
Frame
Bubble trap
Gaskets
Stainless steel 316L ASME
Stainless steel 304L
Glass or acrylic
EPDM or GYLON
Step and Linear Gradient

Step and linear gradient on process chromatography skid size 3 at 1,000 L/H.

Bio-Rad Process Chromatography Skid Schematic

Many options exist for customization of the Bio-Rad process chromatography skid.

Bio-Rad Process Chromatography Skid 00

The versatile Bio-Rad process chromatography skid 00 is a benchtop system for small-scale GMP biopharmaceutical manufacturing processes. The skid 00 is a self-contained system that integrates all necessary hardware components. A wireless tablet PC with SCADA software is used to run the chromatography process and to communicate with the PLC. The housing is made of stainless steel with closed construction design.

Key Features and Benefits

  • Designed for easy cleaning and maintenance
  • Configured for simultaneous inline dilution and gradient operation for high performance and reduced cost
  • User-friendly software meets U.S. FDA 21 CFR Part 11 requirements
  • Documentation for regulatory submission is included

Bio-Rad Process Chromatography Skid 01–05

The Bio-Rad process chromatography skid 01–05 allows different options to be integrated into a core platform. Isocratic and gradient systems are optimized for column diameter and process requirements. Other system components, such as pump size and bubble trap volume, are also designed to order.

You may specify combinations of sensors, including flow, pH, conductivity, temperature, pressure, and air sensors. Other options include the orientation and number of valves and ports, an enhanced pressure rating, and clean-in-place and steam-in-place designs.

Options that can be integrated on a process skid include:

  • Multihead dosing pumps
  • Gradient function (controlled by flow rate or flow rate and conductivity)
  • Additional inlet and outlet valves
  • Pressure sensor (before filter or after column)
  • Additional filter
  • Air sensor (after bubble trap or before pump)
  • Conductivity monitor (before column)
  • Temperature sensor (before column)
  • pH monitor (before column)
  • Sampling valve (after column)
  • HETP software
  • Position detector for valves
  • Sterilization-in-place

The computer-driven operation system is passcode protected to record all events and actions in accordance with GMP compliance guidelines. The system controller runs in the Windows operating system. Its simple, user-friendly interface enables touch-screen input of data and programming commands. The software meets U.S. FDA 21 CFR Part 11 requirements.

For more information, please contact your Bio-Rad process sales representative or technical support.

Bio-Rad Process Chromatography Skid 00

739-3006
Skid, 5–120 L/hr flow rate, 0.2 L bubble trap, for use with process chromatography columns

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Bio-Rad Process Chromatography Skid 01 #739-3010
Bio-Rad Process Chromatography Skid 01

739-3010
Skid, 20–220 L/hr flow rate, 0.8 L bubble trap, for use with process chromatography columns

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Bio-Rad Process Chromatography Skid 02 #739-3020
Bio-Rad Process Chromatography Skid 02

739-3020
Skid, 25–600 L/hr flow rate, 3.5 L bubble trap, for use with process chromatography columns

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Bio-Rad Process Chromatography Skid 03 #739-3030
Bio-Rad Process Chromatography Skid 03

739-3030
Skid, 40–1,000 L/hr flow rate, 5.4 L bubble trap, for use with process chromatography columns

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Bio-Rad Process Chromatography Skid 04 #739-3040
Bio-Rad Process Chromatography Skid 04

739-3040
Skid, 300–3,150 L/hr flow rate, 9.1 L bubble trap, for use with process chromatography columns

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Bio-Rad Process Chromatography Skid 05 #739-3050
Bio-Rad Process Chromatography Skid 05

739-3050
Skid, 450–5,400 L/hr flow rate, 9.1 L bubble trap, for use with process chromatography columns

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Number Description Options
6043 Bio-Rad Chromatography Station 00 Product Information Sheet, Rev B Click to download [ Add to Cart (Free) ]
5997 Bio-Rad Process Chromatography Skid 00 Product Information Sheet, Rev A Click to download [ Add to Cart (Free) ]
5665 Bio-Rad EasyPack Columns Product Information Sheet, Rev B Click to download [ Add to Cart (Free) ]
5663 Bio-Rad InPlace Columns Product Information Sheet, Rev B Click to download [ Add to Cart (Free) ]
6108 Sanitization of the Bio-Rad Process Chromatography Skid 00, Rev A Click to download [ Add to Cart (Free) ]
6091 Innovative Features of Bio-Rad InPlace Chromatography Columns Simplify Packing Procedures for Any Media Type, Rev A Click to download [ Add to Cart (Free) ]
6061 Sanitization of a Packed Bed in the Bio-Rad InPlace Process Chromatography Column, Rev A Click to download [ Add to Cart (Free) ]
5488 State-of-the-Art Solutions for Process-Scale Chromatography, Rev C Click to download [ Add to Cart (Free) ]
5657 Bio-Rad Process Chromatography Skid Product Information Sheet, Rev B Click to download [ Add to Cart (Free) ]
5662 Process Chromatography Applications Laboratory Brochure, Rev B Click to download
5661 Bio-Rad Media Transfer Device, Rev B Click to download [ Add to Cart (Free) ]
5739 Packing and Slurry-in-Place Procedures for CHT Ceramic Hydroxyapatite Using a Bio-Rad InPlace Process-Scale Chromatography Column, Rev B Click to download
5620 Bio-Rad Media Slurry Tank Product Information Sheet, Rev A Click to download
5659 Bio-Rad Mainframe Lifting Accessory Product Information Sheet, Rev B Click to download [ Add to Cart (Free) ]
5614 Bio-Rad Bubble Trap Product Information Sheet, Rev B Click to download
5615 Isolation Two-Way Valves Product Information Sheet, Rev A Click to download
5619 Pressure Relief Valve Product Information Sheet, Rev A Click to download
5616 Liquid Pump for Inflatable Seals Product Information Sheet, Rev B Click to download
5618 Pressure Gauge Product Information Sheet, Rev A Click to download