Bio-Plex Pro™ RBM Human Kidney Toxicity Assays

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Bio-Plex Pro™ RBM Human Kidney Toxicity Assays - Bio-Plex Pro RBM Kidney Toxicity Assays

Overview

Available Bio-Plex Pro™ RBM Human Kidney Toxicity Assays
Human Kidney Toxicity Panel 1
(171-ATR1CK)
Analyte Bead Region
Calbindin 64
Clusterin  12
GST-π 25
IL-18 21
KIM-1 44
MCP-1 15
Human Kidney Toxicity Panel 2
(171-ATR2CK)
Analyte Bead Region
Albumin 30
B2M 22
Cystatin C 51
NGAL 46
Osteopontin 20
TFF3 61

Important Information about Bio-Plex Assay Builder and Custom Assays

The Bio-Plex Assay Builder is currently being updated and validated, and will be back on line in the near future.

During this time, we are unable to process new custom Bio-Plex Express and x-Plex Assays. Please contact us by phone or by email for assistance in selecting available in-stock Bio-Plex Assays to meet your needs.

Bio-Plex Assay Builder

Use the Bio-Plex® Assay Builder to design your customized Bio-Plex Assay in four easy steps

With Assay Builder you can also:

  • Get a price quote
  • Place your order online
  • Look up an existing assay by catalog number
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To design your customized Express or x-Plex assay, process your catalog number, and obtain pricing information, launch the Assay Builder

To create a Bio-Plex custom assay, click Launch Bio-Plex Assay Builder.

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Bio-Plex® Technology and Applications

The Bio-Plex Pro RBM kidney toxicity assays, developed in partnership with Myriad RBM, comprise a highly relevant set of biomarkers for early detection and characterization of kidney toxicity/injury. Myriad RBM’s close collaboration with the Predictive Safety Testing Consortium (PSTC), FDA, and European Medicines Evaluation Agency (EMEA) was instrumental in the selection of markers found in these panels.

The assays are built on magnetic beads to enable robust quantification of multiple proteins in human urine samples, providing valuable information throughout drug development — from lead optimization to preclinical and clinical protocol decision making. Assays are offered as premixed all-in-one kits for research involving:

  • Drug-induced kidney toxicity
  • Diabetes
  • High blood pressure
  • Glomerulonephritis
  • Polycystic kidney disease
  • Chronic infection
  • SLE (lupus) and other autoimmune disorders

Bio-Plex Pro RBM human kidney toxicity assays are available as two panels:

    Panel 1
  • Calbindin
  • Clusterin
  • GST-π
  • IL-18
  • KIM-1
  • MCP-1
    Panel 2
  • Albumin
  • B2M
  • Cystatin C
  • NGAL
  • Osteopontin
  • TFF3

Based on 6.5 µm magnetic beads, these assay panels are compatible with both vacuum and magnetic wash stations. Magnetic washing simplifies plate processing, provides increased throughput, and results in decreased variability and increased reproducibility.

Key Features

  • Optimized for high precision and lot-to-lot reproducibility of sample measurements
  • Magnetic beads for simplified plate processing
  • 2-level quality controls with lot-specific ranges
  • Assay quick guide to get you started right away
  • High-quality design ensures robust and reproducible measurement of nephrotoxicity biomarkers in human, rat, and canine urine samples

Ordering Options

Premixed all-in-one kits

Instrument Compatibility

More Information

See how Bio-Plex instruments and assays benefit researchers studying heart disease, leukemia, melanoma, and other cancers.

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Bio-Plex Pro™ RBM Human Kidney Toxicity Panel 1

171ATR1CK
1 x 96-well, includes magnetic capture beads, detection antibodies, standards, controls, diluent, buffers, streptavidin-PE, flat bottom plate, and plate seals, for the detection of 6 kidney toxicity markers in human urine

List Price:
 
$1,651.00
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Bio-Plex Pro™ RBM Human Kidney Toxicity Panel 2

171ATR2CK
1 x 96-well, includes magnetic capture beads, detection antibodies, standards, controls, diluent, buffers, streptavidin-PE, flat bottom plate, and plate seals, for the detection of 6 kidney toxicity markers in human urine

List Price:
 
$1,651.00
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Number Description Options
6458 Bio-Plex Success Guide/Assay Sample Prep, Rev B Click to download
6335 Bio-Plex® Multiplex Immunoassays Analyte Guide, Interactive PDF, Rev D Click to download [ Add to Cart (Free) ]
10028258 Instruction Manual, Bio-Plex Pro RBM Kidney Toxicity Assays, Rev A Click to download
10028259 Instruction Manual, Bio-Plex Pro RBM Kidney Toxicity Assays Quick Guide, Rev B Click to download
6347 Bio-Plex Pro RBM Assays Product Information Sheet, Rev A Click to download [ Add to Cart (Free) ]
6400 Profiling of Human, Canine, and Rat Urine Samples Using Bio-Plex Pro RBM Kidney Toxicity Assay, Rev A Click to download