The BioPlex® platform offers fully-automated, random access, multiplex testing for clinical diagnostic assays
A Fully-Automated, Random Access, Multiplex Platform
The BioPlex 2200 System is the industry's first and only fully-automated, random access, multiplex testing platform. Combined with a multi-marker, disease-oriented assay menu, internal quality control technologies, and eFlex™ Software, the BioPlex 2200 represents a breakthrough in clinical diagnostic technology. This groundbreaking system offers significant laboratory cost savings through consolidation, decreased labor, and reduced reagent consumption.
Patented Multiplex Detection Magnetic Bead Technology
BioPlex® 2200 immunoassays use heterogeneous sets of magnetic 8 µm beads. The beads are infused with varying ratios of fluorescent dyes, creating unique bead sets. Beads within each set are coated with a ligand (i.e., antigen, antibody, analyte, etc.) specific to a particular assay. Bead sets are then mixed together in a single reagent pack allowing for simultaneous detection of multiple analytes from a single sample.
Each microsphere is dyed with a unique combination of 2 colors.
Example: ANA Screen Kit
The ANA Screen Reagent Pack uses 16 microspheres: 13 assay beads and 3 quality control checks.
Multiplex Chemistry Detection Method
The dual-laser, multiplex flow detection method processes a minimum of 150 individual bead results for each analyte, representing more than 150 assay readings. This enhances the overall quality of each result, when compared to standard immunoassays which rely on a single reading.
Detection 1. A sample of the final reaction mixture is aspirated to the detector.
Detection 2. Bead mixture passes through the detector where one laser identifies the bead analyte and another measures the analyte concentration.
Detection 3. The system detector performs a minimum of 100 measurements per analyte at the rate of 100,000 measurements per minute.
The BioPlex® 2200 fully-automated, random access, multiplex testing platform uses sets of magnetic beads coated with ligands as the basis for a range of autoimmune, infectious disease, and other immunoassays
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